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Methyl iodide → (4-(3-Bromopyridin-2-yloxy)phenyl)(1-methyl-1H-benzo[D]imidazol-2-YL)methanone

HRID 1880022
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반응식

HRID 1880022 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([C:12]1[CH:17]=[CH:16][C:15]([O:18][C:19]2[C:24]([Br:25])=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:14][CH:13]=1)=[O:11].[C:26](=O)([O-])[O-].[Cs+].[Cs+].IC>CN(C=O)C.C(Cl)Cl>[Br:25][C:24]1[C:19]([O:18][C:15]2[CH:14]=[CH:13][C:12]([C:10]([C:2]3[N:3]([CH3:26])[C:4]4[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=4[N:1]=3)=[O:11])=[CH:17][CH:16]=2)=[N:20][CH:21]=[CH:22][CH:23]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 59326957(1H-benzo[d]imidazol-2-yl)(4-(3-bromopyridin-2-yloxy)phenyl)methanone

생성물 1

HCID 59327020(4-(3-Bromopyridin-2-yloxy)phenyl)(1-methyl-1H-benzo[D]imidazol-2-YL)methanone

시약·촉매·용매 2

HCID 6228Dimethylformamide용매
HCID 6344
Dichloromethane
용매

실험 절차

To a solution of (1H-benzo[d]imidazol-2-yl)(4-(3-bromopyridin-2-yloxy)-phenyl)methanone (0.5 g, 1 mmol) in DMF (3 mL) was added cesium carbonate (0.5 g, 2 mmol) and iodomethane (0.2 g, 1 mmol). Reaction was stirred at RT overnight. Reaction mixture was diluted with DCM and washed with water and brine. Purification by prep HPLC produced the desired product.

후처리

  1. customReaction
  2. customReaction mixture
  3. washwashed with water and brine
  4. customPurification by prep HPLC

출처 및 근거

ORD 기록
ord-72eec0d5f6be4c658668efc4fe21a48c
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08318718B2

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