Glutaric anhydride → 5-(4-Methoxyphenyl)-5-oxopentanoic acid

HRID 1881036노트

반응식

HRID 1881036 반응식
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[Cl-].[Al+3].[Cl-].[Cl-].[C:13]([O:16][CH2:17][CH3:18])(=O)C>C1(OC)C=CC=CC=1>[CH3:13][O:16][C:17]1[CH:18]=[CH:4][C:3]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])=[CH:2][CH:1]=1

참가 물질

5

반응물 3

HCID 7940Glutaric anhydrideHCID 8857Ethyl AcetateHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 2668175-(4-Methoxyphenyl)-5-oxopentanoic acid수율 59%

시약·촉매·용매 1

HCID 7519Anisole용매

실험 절차

Glutaric anhydride (10.0 g) was dissolved in anisole (100 mL), aluminum chloride (25.7 g) was added, then stirred for three hours on ice. Ethyl acetate (300 mL) was added to the reaction solution, and the organic layer was washed with water (100 mL) and a saturated sodium chloride solution (100 mL). After drying on anhydrous sodium sulfate, filtration and vacuum condensation, the residue was washed with n-hexane to give the above-identified compound (11.5 g, yield 59%) as a colorless solid.

후처리

  1. washthe organic layer was washed with water (100 mL)
  2. dry with materialAfter drying on anhydrous sodium sulfate, filtration and vacuum condensation
  3. washthe residue was washed with n-hexane

출처 및 근거

ORD 기록
ord-97cb2635ef024ad69aafba46ea483cc4
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318781B2

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