Hydrochloric Acid → 5-Ethoxy-4-hydroxy-2-nitrobenzaldehyde

HRID 1881185노트

반응식

HRID 1881185 반응식
C([O:8][C:9]1[C:16]([O:17][CH2:18][CH3:19])=[CH:15][C:12]([CH:13]=[O:14])=[C:11]([N+:20]([O-:22])=[O:21])[CH:10]=1)C1C=CC=CC=1.Cl>C(O)(=O)C>[CH2:18]([O:17][C:16]1[C:9]([OH:8])=[CH:10][C:11]([N+:20]([O-:22])=[O:21])=[C:12]([CH:15]=1)[CH:13]=[O:14])[CH3:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 123199814-(Benzyloxy)-5-ethoxy-2-nitrobenzaldehyde

생성물 1

HCID 450942415-Ethoxy-4-hydroxy-2-nitrobenzaldehyde

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

4-Benzyloxy-5-ethoxy-2-nitro-benzaldehyde (23 g) was dissolved in acetic acid (93 ml) and concentrated hydrochloric acid (10 ml). The reaction solution was refluxed for 24 hours. Then the solution was evaporated to dryness and the residue was dissolved in diethyl ether. The product was extracted into 1M sodium hydroxide and acidified with 6M hydrochloric acid. The resultant solid was filtered and dried under vacuum.

후처리

  1. temperatureThe reaction solution was refluxed for 24 hours
  2. customThen the solution was evaporated to dryness
  3. dissolutionthe residue was dissolved in diethyl ether
  4. extractionThe product was extracted into 1M sodium hydroxide
  5. filtrationThe resultant solid was filtered
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-a9c9a02e0f0d408dae6ca5b55dcb5a39
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318785B2

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