Hydrogen Bromide → 5,6-Dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid
반응식
C[O:2][C:3]([C:5]1[S:9][C:8]2[C:10]([N+:20]([O-:22])=[O:21])=[C:11]([O:17]CC)[C:12]([O:14]CC)=[CH:13][C:7]=2[CH:6]=1)=[O:4].Br>C(O)(=O)C>[OH:14][C:12]1[C:11]([OH:17])=[C:10]([N+:20]([O-:22])=[O:21])[C:8]2[S:9][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[CH:13]=1참가 물질
4
실험 절차
5,6-Diethoxy-7-nitro-benzo[b]thiophene-2-carboxylic acid methyl ester (160 mg), hydrobromic acid (8 ml) and acetic acid (8 ml) was refluxed for 6 hours and stirred at room temperature overnight. The solid was filtered and washed with a solution of acetic acid and hydrobromic acid (1:1) and water. The product was recrystallized from acetonitrile.
후처리
- filtrationThe solid was filtered
- washwashed with a solution of acetic acid and hydrobromic acid (1:1) and water
- customThe product was recrystallized from acetonitrile
출처 및 근거
- ORD 기록
- ord-00f803d5dd974fc296bd3729dd3baaea
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318785B2
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