4,4'-Dihydroxybiphenyl → Propiconazole 4,4'-dihydroxybiphenyl

HRID 1881246

반응식

HRID 1881246 반응식
[CH3:1][CH2:2][CH2:3][CH:4]1[O:8][C:7]([C:15]2[CH:16]=[CH:17][C:18]([Cl:22])=[CH:19][C:20]=2[Cl:21])([CH2:9][N:10]2[N:14]=[CH:13][N:12]=[CH:11]2)[O:6][CH2:5]1.[OH:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)=[CH:26][CH:25]=1>C(O)C>[CH3:1][CH2:2][CH2:3][CH:4]1[O:8][C:7]([C:15]2[CH:16]=[CH:17][C:18]([Cl:22])=[CH:19][C:20]=2[Cl:21])([CH2:9][N:10]2[N:14]=[CH:13][N:12]=[CH:11]2)[O:6][CH2:5]1.[OH:23][C:24]1[CH:25]=[CH:26][C:27]([C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)=[CH:28][CH:29]=1

참가 물질

4

반응물 2

HCID 71124,4'-Dihydroxybiphenyl2회HCID 43234Propiconazole2회

생성물 1

HCID 86643422Propiconazole 4,4'-dihydroxybiphenyl

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

A 2 litre round bottom flask was set up with overhead stirrer, thermometer, charging funnel and condenser. 405.5 g of propiconazole (technical grade) was charged, with 400 ml of ethanol. The propiconazole solution was agitated for 30 minutes at 40° C. until solubilised. 111.76 g of 4,4′-dihydroxybiphenyl was then added. The reaction mixture was heated to 40° C. Upon heating the 4,4′-dihydroxybiphenyl dissolves to form a clear solution and crystallisation ensues with the formation of a white precipitate. The reaction mixture was agitated for 1 hour at 40° C. and subsequently cooled to 5° C. The solids were isolated by filtration on Buchner apparatus and allowed to dry in air.

후처리

  1. customA 2 litre round bottom flask was set up with overhead stirrer
  2. dissolutiondissolves
  3. customto form
  4. customa clear solution and crystallisation ensues with the formation of a white precipitate
  5. temperaturesubsequently cooled to 5° C
  6. customThe solids were isolated by filtration on Buchner apparatus
  7. customto dry in air

출처 및 근거

ORD 기록
ord-7d4858ddc88149a292909d8b18d6290a
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318789B2

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