Quinoxaline-6-carbohydrazide → Quinoxaline-6-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide

HRID 1881654

반응식

HRID 1881654 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15]([CH3:17])=O)[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8].[N:18]1[C:27]2[C:22](=[CH:23][C:24]([C:28]([NH:30][NH2:31])=[O:29])=[CH:25][CH:26]=2)[N:21]=[CH:20][CH:19]=1>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15](=[N:31][NH:30][C:28]([C:24]3[CH:23]=[C:22]4[C:27](=[CH:26][CH:25]=3)[N:18]=[CH:19][CH:20]=[N:21]4)=[O:29])[CH3:17])[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 4657453Quinoxaline-6-carbohydrazideHCID 442072882-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene

생성물 1

HCID 72359927Quinoxaline-6-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide수율 10%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

A solution of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25 mg, 0.087 mmol) and quinoxaline-6-carboxylic acid hydrazide (25 mg, 0.087 mmol) in dimethylsulfoxide (0.5 mL) was stirred at 100° C. for 12 hours and the reaction mixture was concentrated under the reduced pressure. To the residue was added chloroform and the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 10%).

후처리

  1. concentrationthe reaction mixture was concentrated under the reduced pressure
  2. additionTo the residue was added chloroform
  3. filtrationthe precipitated solid was collected by filtration
  4. customdried by means of a vacuum pump

출처 및 근거

ORD 기록
ord-9a54968d22294922be9a60cd63e9ca03
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318796B2

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