Phenol → Acetic acid, 2-phenoxy-, ethyl ester

HRID 18817

반응식

HRID 18817 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17].CCOCC>CN(C=O)C>[CH2:19]([O:18][C:16](=[O:17])[CH2:15][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:20]

참가 물질

6

반응물 4

HCID 996PhenolHCID 3283Diethyl EtherHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

생성물 1

HCID 17365Acetic acid, 2-phenoxy-, ethyl ester수율 94.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

To a solution of phenol (1.88 g, 20.0 mmol) in DMF (40 mL) is added potassium carbonate (3.03 g, 22.0 mmol) and ethyl bromoacetate (2.34 mL, 21.0 mmol), and the mixture is stirred at 70° C. for 18 h. The mixture is cooled to RT, Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled to give 3.39 g of the product 430.

후처리

  1. temperatureThe mixture is cooled to RT
  2. washthe mixture is washed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customThe filtrate is evaporated
  6. distillationdistilled

출처 및 근거

ORD 기록
ord-02525e846e0e4b539bc293ebb0da1661
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741493B2

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