Sodium Hydroxide → 5-[Bis(methyloxy)methyl]-3-bromo-2-methylpyridine 1-oxide
반응식
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[CH3:12][O:13][CH:14]([O:23][CH3:24])[C:15]1[CH:16]=[C:17]([Br:22])[C:18]([CH3:21])=[N:19][CH:20]=1.C([O-])(O)=O.[Na+].[OH-].[Na+]>C(Cl)Cl>[CH3:24][O:23][CH:14]([O:13][CH3:12])[C:15]1[CH:16]=[C:17]([Br:22])[C:18]([CH3:21])=[N+:19]([O-:9])[CH:20]=1참가 물질
6
실험 절차
m-CPBA (242 mg, 1.052 mmol) was added to a suspension of 5-[bis(methyloxy)methyl]-3-bromo-2-methylpyridine (129.5 mg, 0.526 mmol) and NaHCO3 (133 mg, 1.579 mmol) in DCM (5 ml). The mixture was stirred at room temperature overnight. To the resulting white suspension was added DCM and 1N NaOH. The organic phase was extracted twice,
후처리
- extractionThe organic phase was extracted twice
출처 및 근거
- ORD 기록
- ord-9de1d027737c4d9fa3cd4959679e90a0
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318940B2
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