5,6-Epoxycholest-7-en-3-ol → HCID 57311702, 화합물

HRID 1882912노트

반응식

HRID 1882912 반응식
[O:1]1[C@@H:3]2[CH:4]=[C:5]3[C@@H:21]([C@@:22]4([CH3:28])[CH2:23][CH2:24][C@H:25]([OH:27])[CH2:26][C@@:2]124)[CH2:20][CH2:19][C@@:18]1([CH3:29])[C@H:6]3[CH2:7][CH2:8][C@@H:9]1[C@H:10]([CH3:17])[CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15]>[K]>[CH3:16][CH:14]([CH2:13][CH2:12][CH2:11][C@H:10]([C@@H:9]1[C@:18]2([CH3:29])[C@H:6]([C:5]3[C@H:21]([CH2:20][CH2:19]2)[C@:22]2([CH3:28])[C@@:2]([OH:1])([CH2:26][C@@H:25]([OH:27])[CH2:24][CH2:23]2)[CH2:3][CH:4]=3)[CH2:7][CH2:8]1)[CH3:17])[CH3:15]

참가 물질

3

반응물 1

HCID 1258595,6-Epoxycholest-7-en-3-ol

생성물 1

HCID 57311702HCID 57311702, 화합물수율 35.8%

시약·촉매·용매 1

HCID 5462222Potassium용매

실험 절차

5,6β-Epoxy-5β-cholest-7-en-3β-ol [J. Org. Chem. 50 (1985), 1835] (150 mg) is dissolved in 2.5 ml of a potassium hydroxyde solution (5% in methanol). The reaction mixture is refluxed for one hour. Aqueous work-up, extraction with ethylacetate and column chromatography yields 5β-cholest-7-ene-3β,5β-diol (54 mg).

후처리

  1. temperatureThe reaction mixture is refluxed for one hour
  2. extractionAqueous work-up, extraction with ethylacetate and column chromatography

출처 및 근거

ORD 기록
ord-933004eb1a1442349f69882b0149051f
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06759400B2

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