Hydrochloric Acid → HCID 23508380, 화합물

HRID 1883671노트

반응식

HRID 1883671 반응식
CS([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=O)=O.C[O-].[Na+].O1CCCC1.Cl>CO>[OH:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:12]([C:9]2[CH:10]=[CH:11][C:6]([OH:5])=[CH:7][CH:8]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:19][CH:20]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 10942334Sodium MethoxideHCID 23508424HCID 23508424, 화합물

생성물 1

HCID 23508380HCID 23508380, 화합물수율 60.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture composed of 80 mg of 4-[N-(4-hydroxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate and 0.5 ml of a 28% methanolic solution of sodium methoxide was stirred in 2 ml of methanol and 1 ml of tetrahydrofuran at 50° C. for 1hour. After hydrochloric acid was added to the reaction mixture, the product was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was distilled off the resulting crude product was purified by TLC (using a 19:1 mixture of chloroform and methanol as the developing solvent) to obtain 38 mg of N-(4-hydroxybenzyl)-N-(4-hydroxyphenyl)methanesulfonamide.

후처리

  1. extractionthe product was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off the resulting crude product
  5. customwas purified by TLC (
  6. additiona 19:1 mixture of chloroform and methanol as the developing solvent)

출처 및 근거

ORD 기록
ord-55c0d43bf4bb4e05802f0e0efd39347d
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762205B1

반응 노트

불러오는 중…