Hydrochloric Acid → 3-hydroxy-N-(2-hydroxyphenyl)benzamide

HRID 1883697

반응식

HRID 1883697 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15]C)=[O:7].Cl.N1C=CC=CC=1.Cl>>[OH:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])=[O:7]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 9028663-methoxy-N-(2-methoxyphenyl)benzamideHCID 10176127Pyridinium chloride

생성물 1

HCID 235084853-hydroxy-N-(2-hydroxyphenyl)benzamide수율 27.1%

반응 조건

온도
190 °C

실험 절차

451 mg of 3-methoxy-N-(2-methoxyphenyl)benzamide and 1.58 g of pyridine hydrochloride were mixed, and stirred on an oil bath at 190° C. for 2 hours. After cooling, dilute hydrochloric acid was added to the reaction mixture, and the product was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium hydrogen carbonate and dried over anhydrous sodium sulfate. After the solvent was distilled oft the resulting crude product was recrystallized from methanol to obtain 109 mg of 3-hydroxy-N-(2-hydroxyphenyl)benzamide.

후처리

  1. temperatureAfter cooling
  2. extractionthe product was extracted with ethyl acetate
  3. washThe extract was washed with a saturated aqueous solution of sodium hydrogen carbonate
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationAfter the solvent was distilled oft the resulting crude product
  6. customwas recrystallized from methanol

출처 및 근거

ORD 기록
ord-6e4d1a4308d040539db3d1486d9713c0
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762205B1

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