Hydrochloric Acid → HCID 23508318, 화합물
반응식
C([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH:14]([CH3:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:9]2[C:13]=1[CH2:12][CH2:11][CH2:10]2)(=O)C.[ClH:22]>>[ClH:22].[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH:14]([CH3:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:9]2[C:13]=1[CH2:12][CH2:11][CH2:10]2참가 물질
3
반응 조건
- 온도
- 118 °C
실험 절차
Ethyl 3-[7-acetylamino-indan-4-yl]-butanoate (1.66 g, Reference Example 6) was treated with 6M aqueous hydrochloric acid. The stirred mixture was heated at 118° C. for 4 hours, then left to stand at room temperature for 48 hours and then evaporated. The residue was treated with ethanol (100 mL) and concentrated hydrochloric acid (4 drops). This mixture was heated at reflux for 2.5 hours, then allowed to stand at room temperature for 16 hours and then evaporated. The residue was dissolved in a little ethanol and the solution was evaporated. The residue was dried under high vacuum to give the title compound (1.57 g) as a fine solid.
후처리
- waitleft
- custom