Hydrochloric Acid → 4-Penten-2-ol, 1,1,1-trifluoro-2-(trifluoromethyl)-

HRID 1883940

반응식

HRID 1883940 반응식
[F:1][C:2]([F:10])([F:9])[C:3]([C:5]([F:8])([F:7])[F:6])=[O:4].[CH2:11](Br)[CH:12]=[CH2:13].Cl>C1COCC1>[CH2:13]([C:3]([OH:4])([C:5]([F:8])([F:7])[F:6])[C:2]([F:10])([F:9])[F:1])[CH:12]=[CH2:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7841Allyl bromideHCID 12695Hexafluoroacetone

생성물 1

HCID 3288704-Penten-2-ol, 1,1,1-trifluoro-2-(trifluoromethyl)-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

One mol of hexafluoroacetone was added dropwise at 0° C. to 1.1 mol of allylbromide in THF solution. The reaction was carried out at room temperature for 4 hours. After treating with HCl, the reaction mixture was extracted with H2O and ether, and the organic layer was evaporated under reduced pressure to provide an intermediate product, allylhexafluoroisopropanol. Cyclopentadiene (1 mol) and 1 mol of the intermediate product then were placed into a reactor and reacted at about 80° C. for about 24 hours.

후처리

  1. extractionthe reaction mixture was extracted with H2O and ether
  2. customthe organic layer was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-76561a4c03834dd59c082c51908e0bfa
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762268B2

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