Nitro-4-(3-fluoro-phenoxymethyl)-benzene → 4-(3-Fluoro-phenoxymethyl)-phenylamine

HRID 1884111노트

반응식

HRID 1884111 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pt]>[F:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

참가 물질

4

반응물 1

HCID 22137955Nitro-4-(3-fluoro-phenoxymethyl)-benzene

생성물 1

HCID 167938064-(3-Fluoro-phenoxymethyl)-phenylamine수율 112.8%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 887Methanol용매

실험 절차

g (4 mmol) of 1-Nitro-4-(3-fluoro-phenoxymethyl)-benzene in 40 ml methanol is treated with 0.25 g of 5% platinum on charcoal and hydrogenated for 1 h at room temperature and normal pressure. The catalyst is filtered and the solution evaporated to yield 0.98 g of the crude title compound as yellow oil. MS: m/e=218.3 (M++H).

후처리

  1. filtrationThe catalyst is filtered
  2. customthe solution evaporated

출처 및 근거

ORD 기록
ord-52d409f3b37340bd990487ae23b9bf8c
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762320B2

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