HCID 12150103, 화합물 → HCID 12150104, 화합물

HRID 1884608노트

반응식

HRID 1884608 반응식
C([O:5][C:6]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:25]=[C:24]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:23]=2[O:37][CH3:38])=[O:20])=[CH:10][CH:9]=1)=[O:7])(C)(C)C>[Au].C(O)(C(F)(F)F)=O>[C:28]([C:26]1[CH:25]=[C:24]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:23]([O:37][CH3:38])=[C:22]([NH:21][C:19](=[O:20])[NH:18][C:11]2[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]([C:6]([OH:7])=[O:5])=[CH:9][CH:10]=2)[CH:27]=1)([CH3:31])([CH3:29])[CH3:30]

참가 물질

4

반응물 1

HCID 12150103HCID 12150103, 화합물

생성물 1

HCID 12150104HCID 12150104, 화합물수율 89%

시약·촉매·용매 2

HCID 23985Gold촉매HCID 6422Trifluoroacetic acid용매

실험 절차

To a 0° C. solution of 10 mL of TFA was added 878 mg (1.9 mmol) of 4-[3-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalene-1-carboxylic acid tert-butyl ester. The clear, light gold reaction was allowed to warm to room temperature, and kept there for 1 h. After this time, the reaction was concentrated in vacuo, and then diluted with toluene. The toluene was then removed in vacuo and the pale white solid was triturated with ether to provide 682 mg (89%) of the title compound.

후처리

  1. concentrationAfter this time, the reaction was concentrated in vacuo
  2. additiondiluted with toluene
  3. customThe toluene was then removed in vacuo
  4. customthe pale white solid was triturated with ether

출처 및 근거

ORD 기록
ord-a74cbf86aec6495b880a69bcde8de4c6
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06765009B2

반응 노트

불러오는 중…