Water → 1-(Hexadecyloxy)but-3-EN-2-OL

HRID 1885452

반응식

HRID 1885452 반응식
[H-].[Na+].[CH2:3]([OH:8])[C:4]([OH:7])=[CH:5][CH3:6].[CH2:9](Br)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].O>CN(C)C=O>[CH2:24]([O:8][CH2:3][CH:4]([OH:7])[CH:5]=[CH2:6])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH3:9]

참가 물질

6

반응물 4

HCID 962WaterHCID 82131-BromohexadecaneHCID 24758Sodium hydrideHCID 396052-Butene-1,2-diol

생성물 1

HCID 139590711-(Hexadecyloxy)but-3-EN-2-OL

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

To 18.5 q of washed sodium hydride in 500 ml of dry dimethylformamide in a water bath is added dropwise, 67.4 q of 2-butene-1,2-diol. A solution of 235 g of hexadecylbromide in 100 ml of dimethylformamide is added dropwise. This mixture is stirred at room temperature for 2 days then poured into water and extracted with ether. The ether extract is separated, dried, evaporated and purified by chromatography, to give 30 g of the desired compound.

후처리

  1. extractionextracted with ether
  2. extractionThe ether extract
  3. customis separated
  4. customdried
  5. customevaporated
  6. custompurified by chromatography

출처 및 근거

ORD 기록
ord-b8eb975f2b1142f4bd5c183f6415b3a0
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05144045

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