홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Acetonitrile → 3-Acetoxy-7alpha-(11-acetoxyundecyl)-1,3,5(10)-estratrien-17-one

HRID 1885558
노트
인쇄 미리보기

반응식

HRID 1885558 반응식
[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]1[CH2:33][C:32]2[C@H:27]([CH2:28][CH2:29][C:30](=[O:34])[CH:31]=2)[C@@H:26]2[C@@H:17]1[C@H:18]1[C@@:22]([CH2:24][CH2:25]2)([CH3:23])[C:21](=[O:35])[CH2:20][CH2:19]1)(=[O:3])[CH3:2].[Br-].[Li+].[C:38](=[O:41])(O)[O-].[Na+].[C:43](#N)C>[Cu](Br)Br>[C:38]([O:34][C:30]1[CH:29]=[CH:28][C:27]2[C@@H:26]3[C@H:17]([C@H:18]4[C@@:22]([CH2:24][CH2:25]3)([CH3:23])[C:21](=[O:35])[CH2:20][CH2:19]4)[C@H:16]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][O:4][C:1](=[O:3])[CH3:2])[CH2:33][C:32]=2[CH:31]=1)(=[O:41])[CH3:43]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6342Acetonitrile2회HCID 82050Lithium BromideHCID 516892Sodium BicarbonateHCID 57202929HCID 57202929, 화합물

생성물 1

HCID 150861223-Acetoxy-7alpha-(11-acetoxyundecyl)-1,3,5(10)-estratrien-17-one

시약·촉매·용매 1

HCID 24611
Copper bromide (CuBr2)
촉매

실험 절차

10.5 g of 7α-(11-acetoxyundecyl)-4-estrene-3,17-dione in 58.5 ml of acetonitrile is added to a solution of 9.1 g of copper(II) bromide and 1.78 g of lithium bromide in 141 ml of acetonitrile and heated under reflux for 0.5 hour. Then the mixture is cooled to 0°, gradually combined with 235 ml of sodium bicarbonate solution, extracted three times with ethyl acetate, washed with water and sodium chloride solution, dried over sodium sulfate, concentrated to dryness under vacuum, and chromatographed on silica gel with hexane/ethyl acetate, thus obtaining 7.5 g of 3-acetoxy-7α-(11-acetoxyundecyl)-1,3,5(10)-estratrien-17-one, [α]D =75.8°, as an oil.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 0.5 hour
  3. temperatureThen the mixture is cooled to 0°
  4. extractionextracted three times with ethyl acetate
  5. washwashed with water and sodium chloride solution
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated to dryness under vacuum
  8. customchromatographed on silica gel with hexane/ethyl acetate

출처 및 근거

ORD 기록
ord-894a2cbc5d2a499d9fa7a81ebe45fe47
출처 데이터셋
uspto-grants-1992_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05145847

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트