1,6-Dibromohexane → 2-[3-[(6-Bromohexyl)oxy]propyl]quinoline

HRID 1886033노트

반응식

HRID 1886033 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH2:13][OH:14].[OH-].[Na+].[Br:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]Br>O.CCOCC>[Br:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][O:14][CH2:13][CH2:12][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1

참가 물질

6

반응물 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 218061343-(Quinolin-2-yl)propan-1-ol

생성물 1

HCID 198767552-[3-[(6-Bromohexyl)oxy]propyl]quinoline

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

2-Quinolinepropanol (0.92 g), 50% aqueous sodium hydroxide (5 ml), 1,6-dibromohexane (5 ml) and TAB (57 mg) were vigorously stirred at 21° for 6 h. The mixture was diluted with water (25 ml) and ether (100 ml) and the organic phase dried and evaporated in vacuo. The residue was purified by FCC with hexane eluant to remove 1,6-dibromohexane. Elution with ether afforded the title compound as a yellow oil (0.88 g), t.l.c. ether Rf 0.51.

후처리

  1. customthe organic phase dried
  2. customevaporated in vacuo
  3. customThe residue was purified by FCC with hexane eluant
  4. customto remove 1,6-dibromohexane
  5. washElution with ether

출처 및 근거

ORD 기록
ord-72fc97cfd6b24beeb8cfedffad248d1c
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149698

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