Sodium Hydroxide → HCID 19876826, 화합물

HRID 1886039노트

반응식

HRID 1886039 반응식
CS([C:5]1[N:9]([CH3:10])[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[N:6]=1)(=O)=O.[C:15]([NH:18][CH2:19][CH2:20][NH2:21])(=[O:17])[CH3:16].[OH-].[Na+]>O>[CH3:10][N:9]1[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[N:6]=[C:5]1[NH:21][CH2:20][CH2:19][NH:18][C:15](=[O:17])[CH3:16]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 66082N-(2-aminoethyl)acetamideHCID 6407151H-benzimidazole, 1-methyl-2-(methylsulfonyl)-

생성물 1

HCID 19876826HCID 19876826, 화합물수율 30%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2-methylsulfonyl-1-methyl-1H-benzimidazole (7.0 g, 0.033 mol) and N-acetylethylenediamine (17.0 g, 0.167 mol) was heated at 120°-125° C. for 8 hours. The mixture was cooled, diluted with H2O, made basic (pH8) with 2.5N NaOH, and filtered. The filtrate was extracted with EtOAc, and the combined extracts were washed with brine, dried, and concentrated to give a yellow solid 2.3 g (30%).

후처리

  1. temperaturewas heated at 120°-125° C. for 8 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. extractionThe filtrate was extracted with EtOAc
  5. washthe combined extracts were washed with brine
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-30c1f321743f4c65893aa24b4c8df49f
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149700

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