Phenol → HCID 14789659, 화합물

HRID 1886097노트

반응식

HRID 1886097 반응식
CN(C[C@@H:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C@H:6]1[OH:14])C.[C:15]1(O)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[N:22]([C:29](OCC)=O)=NC(OCC)=O.O1CCC[CH2:35]1>>[O:14]([C@@H:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:13][C@H:5]1[N:22]([CH3:29])[CH3:35])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 4

HCID 996PhenolHCID 8028Tetrahydrofuran2회HCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 22845150HCID 22845150, 화합물

생성물 1

HCID 14789659HCID 14789659, 화합물

실험 절차

Stir a solution of TRANS-2,3-dihydro-2-dimethylamino methyl-inden-1-ol (7.65 g, 0.04 M) triphenylphosphine (11.54 g, 0.044 M), and phenol (4.14 g, 0.044 M) in 100 ml of tetrahydrofuran. Slowly add a solution of diethyl azodicarboxylate in 50 ml of tetrahydrofuran dropwise. Stir the mixture overnight and evaporate the solvent. Take up the residue in ether, filter insoluble material and reconcentrate. Chromatograph the residue on silica gel eluting with ether to yield two isomers, CIS and TRANS, with the CIS isomer eluting first.

후처리

  1. customevaporate the solvent
  2. filtrationfilter insoluble material and reconcentrate
  3. customChromatograph the residue on silica gel eluting with ether to yield two isomers, CIS
  4. washeluting first

출처 및 근거

ORD 기록
ord-e54fde7e00b444fabcba31c2e01a8436
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149714

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