Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 1886742

반응식

HRID 1886742 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

생성물 1

HCID 2474Bupivacaine (USAN:INN:BAN)

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

후처리

  1. customto precipitate the Bupivacaine base
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

출처 및 근거

ORD 기록
ord-810d63d043b34203ab16d47ebf78540b
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501215B2

연결된 노트

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