Hydrochloric Acid → Ethyl 2-(1-benzylcyclohexyl)-2-cyanoacetate

HRID 1886898노트

반응식

HRID 1886898 반응식
[CH2:1]([Mg]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([C:12](=[C:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])#[N:11].Cl>C(OCC)C>[CH2:1]([C:18]1([CH:12]([C:10]#[N:11])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 81256Ethyl cyanocyclohexylideneacetateHCID 178418336HCID 178418336, 화합물

생성물 1

HCID 14435569Ethyl 2-(1-benzylcyclohexyl)-2-cyanoacetate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

1 M Benzylmagnesium chloride in diethyl ether (18.92 ml) was added dropwise to ethyl 2-cyano-2-cyclohexylideneacetate (1.828 g, 9.46 mmol) in diethyl ether (6.31 ml) at 23° C. The mixture was stirred at room temperature for 3 days. Then 10% hydrochloric acid (7.83 ml, 255 mmol) was added dropwise at 0° C. while stirring. The organic layer was separated, washed with water, dried over Na2SO4, filtered, and concentrated.

후처리

  1. stirringwhile stirring
  2. customThe organic layer was separated
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-38c9284ead934dc5b600d20cbdad8608
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501722B2

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