Phenyl isocyanate → 1-Phenyl-3-(2-phenylbenzo[d]oxazol-5-yl)urea

HRID 1886919

반응식

HRID 1886919 반응식
[C:1]1([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17]1([N:23]=[C:24]=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>ClCCl>[C:17]1([NH:23][C:24]([NH:16][C:13]2[CH:14]=[CH:15][C:9]3[O:8][C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[N:11][C:10]=3[CH:12]=2)=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 7210592-Phenyl-1,3-benzoxazol-5-amine

생성물 1

HCID 673325081-Phenyl-3-(2-phenylbenzo[d]oxazol-5-yl)urea수율 85%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 2-phenylbenzo[d]oxazol-5-amine (75 mg, 0.36 mmol) in dichloromethane (2 mL) at room temperature was added phenyl isocyanate (43 μL, 0.39 mmol). The solution was stirred at room temperature for 16 h. The resulting precipitate was filtered off and washed with dichloromethane to afford 99.9 mg (85%) of the title compound (LCMS RT=6.45 min, MH+ 330.1)

후처리

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with dichloromethane

출처 및 근거

ORD 기록
ord-c3b535fff2704f91b0ee1b438bd2f08f
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501713B2

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