Ethyl Acetate → HCID 67331269, 화합물

HRID 1886953노트

반응식

HRID 1886953 반응식
C[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[CH:3]1.[C:12](Cl)(=[O:16])[CH:13]([CH3:15])[CH3:14].C(OCC)(=O)C>N1C=CC=CC=1>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[CH:9]=2)[CH:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 62325Isobutyryl chlorideHCID 105347991-methyl-1H-indol-6-amine

생성물 1

HCID 67331269HCID 67331269, 화합물수율 38.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 1-methyl-1H-indol-6-amine (45 mg, 0.31 mmol) in pyridine (2 mL) at room temperature was added isobutyryl chloride (35 μL, 0.34 mmol). The resulting mixture was stirred at room temperature for 16 h. Ethyl acetate was added and the organic layer was washed three times with brine. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 24.3 mg (36%) of the title compound (LCMS RT=5.73 min, MH+ 217.2)

후처리

  1. washthe organic layer was washed three times with brine
  2. dry with materialThe combined organic layers were dried over anhydrous MgSO4
  3. customevaporated

출처 및 근거

ORD 기록
ord-530a392fde554c979fa63a2e873ffb0a
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501713B2

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