Hydrochloric Acid → 1,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid (4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4-a-diaza-benzocyclohepten-9-yl)-amide hydrochloride

HRID 1886967노트

반응식

HRID 1886967 반응식
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:18](=[O:38])[NH:19][CH:20]3[C:26]4=[N:27][C:28]([C:32]5[CH:37]=[CH:36][N:35]=[CH:34][N:33]=5)=[CH:29][C:30](=[O:31])[N:25]4[CH2:24][CH2:23][O:22][CH2:21]3)=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:39]>ClCCl>[ClH:39].[O:31]=[C:30]1[N:25]2[C:26]([CH:20]([NH:19][C:18]([C:12]3[CH:11]=[C:10]4[C:15]([CH2:16][CH2:17][NH:8][CH2:9]4)=[CH:14][CH:13]=3)=[O:38])[CH2:21][O:22][CH2:23][CH2:24]2)=[N:27][C:28]([C:32]2[CH:37]=[CH:36][N:35]=[CH:34][N:33]=2)=[CH:29]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 44159737HCID 44159737, 화합물

생성물 1

HCID 866498491,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid (4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4-a-diaza-benzocyclohepten-9-yl)-amide hydrochloride수율 70%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 0.049 g (0.10 mmol) of (+/−)-7-(4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4-a-diaza-benzocyclohepten-9-ylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (example 1) dissolved in 0.5 mL of dichloromethane was added 0.24 mL (0.96 mmol) of hydrochloric acid (4M in dioxane). The resulting mixture was stirred at room temperature for 2.5 hours. The resulting residue was filtered, washed with dichloromethane and isopropylether to afford 0.031 g (70%) of the pure product as a yellow powder.

후처리

  1. filtrationThe resulting residue was filtered
  2. washwashed with dichloromethane and isopropylether

출처 및 근거

ORD 기록
ord-54a47bbc66724967a22e644acfdf4d13
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501728B2

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