Hydrochloric Acid → HCID 58303835, 화합물

HRID 1886981노트

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HRID 1886981 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:10]=1Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.O.O.O.O.O.O.O.O.[S-2:28].[Na+].[Na+].CCOCC.Cl>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:10]=1[SH:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 73972Sodium sulfide nonahydrateHCID 143561211-(Benzyloxy)-2-chloro-3-nitrobenzene

생성물 1

HCID 58303835HCID 58303835, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
22 °C

실험 절차

To a solution of 8.56 g (32.5 mmol) of 1-(benzyloxy)-2-chloro-3-nitrobenzene in 120 mL of DMF was added 15.6 g (64.9 mmol) of pulverized sodium sulfide nonahydrate. The mixture was stirred vigorously at 22° C. for 30 hours and then poured into a vigorously stirred mixture of ether and 1 N HCl. The organic layer was washed with water then brine, dried (Na2SO4), and evaporated. The residue was crystallized from dichloromethane (DCM) and hexane to give 2-(benzyloxy)-6-nitrobenzenethiol.

후처리

  1. washThe organic layer was washed with water
  2. dry with materialbrine, dried (Na2SO4)
  3. customevaporated
  4. customThe residue was crystallized from dichloromethane (DCM) and hexane

출처 및 근거

ORD 기록
ord-1a9ba1d883fc4afa9f25825215dda737
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501727B2

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