2-Amino-5-chlorobenzophenone → N-(2-benzoyl-4-chloro-phenyl)-2,4-dichloro-benzenesulfonamide

HRID 18871

반응식

HRID 18871 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[S:25](Cl)(=[O:27])=[O:26]>>[C:9]([C:3]1[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=1[NH:1][S:25]([C:19]1[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:18]=1[Cl:17])(=[O:27])=[O:26])(=[O:10])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

3

반응물 2

HCID 128702-Amino-5-chlorobenzophenoneHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-

생성물 1

HCID 11247683N-(2-benzoyl-4-chloro-phenyl)-2,4-dichloro-benzenesulfonamide

실험 절차

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 115 mg of (2-amino-5-chloro-phenyl)-phenyl-methanone and 123 mg of 2,4-dichloro-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 7.24 (m, 1H), 7.31 (m, 1H), 7.45 (m, 2H), 7.54 (m, 2H), 7.60-7.65 (m, 2H), 7.97 (d, 1H, J=8.4 Hz), 10.23 (s, 1H). MS: m/z 440.7 (M++1).

출처 및 근거

ORD 기록
ord-c371b57b7eb2404e8edfb0b27e2bf8ac
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741519B2

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