반응식
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[C:5]([C:15]([F:18])([F:17])[F:16])=[CH:4][N:3]=1.[CH3:19][O:20][C:21]1[CH:27]=[C:26]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[CH:25]=[CH:24][C:22]=1[NH2:23].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.[C:76](=[O:79])([O-])[O-:77].[Cs+].[Cs+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:76]([OH:77])([C:15]([F:18])([F:17])[F:16])=[O:79].[CH3:19][O:20][C:21]1[CH:27]=[C:26]([N:28]2[CH2:29][CH2:30][O:31][CH2:32][CH2:33]2)[CH:25]=[CH:24][C:22]=1[NH:23][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[C:5]([C:15]([F:18])([F:17])[F:16])=[CH:4][N:3]=1참가 물질
8
반응물 4
생성물 2
시약·촉매·용매 2
실험 절차
Method A was applied to a mixture of N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-2-amine (16 mg, 0.059 mmol), 2-methoxy-4-morpholinoaniline (17 mg, 0.082 mmol), Pd2(dba)3 (6 mg, 0.0066 mmol), xantphos (5.5 mg, 0.0095 mmol) and cesium carbonate (43 mg, 0.13 mmol) in dioxane (3 ml). The bis-TFA salt of the title compound was obtained as a yellow solid.
출처 및 근거
- ORD 기록
- ord-9359eecd6d9647209b33bfacdc01cf7d
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08501763B2
연결된 노트
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