HCID 86649074, 화합물 → 3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one

HRID 1887730노트

반응식

HRID 1887730 반응식
C([C@H]([C@@H](C(O)=O)O)O)(O)=O.[NH2:11][CH:12]1[CH2:21][C:20]2[C:15](=[C:16]([N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])[CH:17]=[CH:18][CH:19]=2)[N:14]([CH2:28][C:29]2[CH:33]=[CH:32][S:31][CH:30]=2)[C:13]1=[O:34]>C(Cl)(Cl)Cl>[NH2:11][CH:12]1[CH2:21][C:20]2[C:15](=[C:16]([N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])[CH:17]=[CH:18][CH:19]=2)[N:14]([CH2:28][C:29]2[CH:33]=[CH:32][S:31][CH:30]=2)[C:13]1=[O:34]

참가 물질

3

반응물 1

HCID 86649074HCID 86649074, 화합물

생성물 1

HCID 596203303-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one수율 86.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3-Amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one D-(−)-tartrate (254 g) was suspended in chloroform (1.3 L), and the suspension was extracted with saturated aqueous sodium bicarbonate solution (1.3 L). The organic layers were combined, and the combined organic layer was dried over sodium sulfate. The solvent was evaporated, and ethyl acetate was added to the thus-recovered residue. The precipitates were recovered through filtration and dried, whereby the title compound (153 g) was yielded.

후처리

  1. extractionthe suspension was extracted with saturated aqueous sodium bicarbonate solution (1.3 L)
  2. dry with materialthe combined organic layer was dried over sodium sulfate
  3. customThe solvent was evaporated
  4. additionethyl acetate was added to the thus-recovered residue
  5. filtrationThe precipitates were recovered through filtration
  6. customdried

출처 및 근거

ORD 기록
ord-6ce95a4621b740ddb3588f62a0d0a622
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501772B2

반응 노트

불러오는 중…