4-Carbamoylbenzoic acid → N-(7-Chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-terephthal-amide

HRID 1887834

반응식

HRID 1887834 반응식
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:4]=1[C:21]1[O:22][CH:23]=[CH:24][N:25]=1.[NH2:26][C:27]([C:29]1[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=1)=[O:28]>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:33](=[O:34])[C:32]3[CH:36]=[CH:37][C:29]([C:27]([NH2:26])=[O:28])=[CH:30][CH:31]=3)=[C:4]([C:21]3[O:22][CH:23]=[CH:24][N:25]=3)[N:5]2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 5060574-Carbamoylbenzoic acidHCID 712083323-aminomethyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one

생성물 1

HCID 71208768N-(7-Chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-terephthal-amide

실험 절차

N-(7-Chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-terephthal-amide was prepared starting from intermediate A and 4-(aminocarbonyl)benzoic acid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.40 (t, J=4.50 Hz, 1H) 8.31 (d, J=8.59 Hz, 1H) 8.02 (br. s, 1H) 7.97 (d, J=0.78 Hz, 1H) 7.83-7.87 (m, 2H) 7.73-7.78 (m, 2H) 7.37-7.54 (m, 7H) 7.16 (d, J=0.78 Hz, 1H) 6.72 (d, J=1.56 Hz, 1H) 4.25 (d, J=4.30 Hz, 2H). MS calcd. for C27H19ClN4O4 [(M+H)+] 499.1, obsd. 499.

출처 및 근거

ORD 기록
ord-2c8178998d65439f9536359e55e53d4d
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501732B2

연결된 노트

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