Hydrazine hydrate (1:1) → HCID 178451811, 화합물

HRID 1888207노트

반응식

HRID 1888207 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:24]#[N:25])[C:5](F)=[C:6]([C:8]([CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]2)=O)[CH:7]=1.O.[NH2:27][NH2:28]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]2[C:5](=[C:4]([C:24]#[N:25])[CH:3]=1)[NH:28][N:27]=[C:8]2[CH:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 59022871HCID 59022871, 화합물

생성물 1

HCID 178451811HCID 178451811, 화합물수율 59%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1,1-dimethylethyl 4-[(5-bromo-3-cyano-2-fluorophenyl)carbonyl]-1-piperidinecarboxylate (1.35 g, 3.3 mmols) and hydrazine hydrate (0.21 ml, 6.9 mmols) in ethanol (30 mL) was heated at reflux overnight. After cooling, the solvent was evaporated and the residue was purified by flash chromatography eluting with pentane/ethyl acetate 4:1 v/v to give the title compound (0.78 g) as a yellow solid (59%).

후처리

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. temperatureAfter cooling
  4. customthe solvent was evaporated
  5. customthe residue was purified by flash chromatography
  6. washeluting with pentane/ethyl acetate 4:1 v/v

출처 및 근거

ORD 기록
ord-df771e4b77904824b85a5327e4120681
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501780B2

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