Potassium Hydroxide → HCID 178451813, 화합물

HRID 1888208노트

반응식

HRID 1888208 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O-:21])=[O:20])[CH2:15][CH2:14]1.[OH-:22].[K+]>CC(O)(C)C>[NH2:12][C:11]([C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]2[C:8]=1[NH:7][N:6]=[C:5]2[CH:13]1[CH2:14][CH2:15][N:16]([C:19]([O:21][C:4]([CH3:8])([CH3:5])[CH3:3])=[O:20])[CH2:17][CH2:18]1)=[O:22]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 178509435HCID 178509435, 화합물

생성물 1

HCID 178451813HCID 178451813, 화합물수율 191.5%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

To 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (0.30 g, 0.74 mmols) in 2-methyl-2-propanol (30 mL) was added KOH (0.45 g, 7.4 mmol). The reaction mixture was heated at reflux overnight. After cooling, the solvent was evaporated and the residue was redissovled in ethyl acetate (150 mL) and filtered through a pad of silica gel to give the title compound (300 mg) as a yellow solid (99%).

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux overnight
  3. temperatureAfter cooling
  4. customthe solvent was evaporated
  5. filtrationfiltered through a pad of silica gel

출처 및 근거

ORD 기록
ord-6f971cba14fc424a903f576721d2ba23
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501780B2

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