Triethylamine → HCID 178477699, 화합물

HRID 1888277

반응식

HRID 1888277 반응식
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[C:12]([C:23]([NH2:25])=[O:24])[CH:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1.[CH2:26]([S:28](Cl)(=[O:30])=[O:29])[CH3:27].C(N(CC)CC)C>C(Cl)Cl>[CH2:26]([S:28]([N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[C:12]([C:23]([NH2:25])=[O:24])[CH:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1)(=[O:30])=[O:29])[CH3:27]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 11667Ethanesulfonyl chlorideHCID 178479540HCID 178479540, 화합물2회

생성물 1

HCID 178477699HCID 178477699, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

This compound was prepared in a fashion analogous to the procedure described in Example 3. Thus 3-(4-piperidinyl)-5-(3-pyridinyl)-1H-indazole-7-carboxamide hydrochloride (Intermediate 21) (0.09 mmol) was reacted with ethane sulfonyl chloride (0.01 mL, 0.217 mmol) in the presence of triethylamine (0.04 mL, 0.468 mmol) in methylene chloride (10 mL) to give the title compound (4.9 mg, 13% for the last two steps)

후처리

  1. customThis compound was prepared in a fashion analogous to the procedure

출처 및 근거

ORD 기록
ord-06aebaefeaeb4ed088fcd0e4819e3401
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501780B2

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