Ammonia → HCID 178441303, 화합물

HRID 1888684

반응식

HRID 1888684 반응식
[C:1]([N:5]1[CH:9]=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[C:7](=[NH:14])[S:6]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([OH:28])(=O)[C:16]1([CH2:26][CH2:25][CH:21]([C:22](O)=[O:23])[C:18]1([CH3:20])[CH3:19])[CH3:17].[NH3:29]>CO>[CH2:10]([C:8]1=[CH:9][N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6]/[C:7]/1=[N:14]\[C:22]([C@H:21]1[CH2:25][CH2:26][C@@:16]([CH3:17])([C:15]([NH2:29])=[O:28])[C:18]1([CH3:20])[CH3:19])=[O:23])[CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 214911,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acidHCID 668672282-tert-Butyl-4-butylisothiazol-5(2H)-imine

생성물 1

HCID 178441303HCID 178441303, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The product from Example 92B and the (+) camphoric acid (Aldrich) were processed using the method described in Example 170 except that the methanol used to trap the intermediate was saturated with ammonia solution instead of methanol to afford the title compound. 1H NMR (DMSO-d6) δ 0.50 (s, 3H), 0.90 (t, J=7.2 Hz, 3H), 1.19 (s, 3H), 1.23-1.44 (m, 3H), 1.26 (s, 3H), 1.57 (s, 9H), 1.57-1.71 (m, 3H), 1.93-2.06 (m, 1H), 2.71-2.82 (m, 1H), 2.62-2.69 (m, 3H), 7.01 (s, 1H), 6.75 (s, 1H), 8.50 (s, 1H). MS (ESI+) m/z 394 (M+H)+. Anal. calcd. for C11H35N3O2S: C, 64.08; H, 8.96; N, 10.68. Found: C, 64.26; H, 9.10; N, 10.65.

후처리

  1. customused to trap

출처 및 근거

ORD 기록
ord-a7405d8924b6428ca7d618916c83d8e4
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501794B2

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