Iodoethane → 3-Bromo-4-ethoxybenzyl alcohol

HRID 1888767노트

반응식

HRID 1888767 반응식
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[OH:10].I[CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 1215942-Bromo-4-hydroxymethylphenol

생성물 1

HCID 580476873-Bromo-4-ethoxybenzyl alcohol수율 87.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-bromo-4-(hydroxymethyl)phenol (3.00 g, 14.7 mmol), iodoethane (4.60 mL, 44.3 mmol) and potassium carbonate (6.12 g, 44.3 mmol) in ethanol (30 mL) was stirred at room temperature for 2 days. The obtained reaction mixture was filtered through celite, and the solvent was evaporated under reduced pressure. The residue was applied to silica gel chromatography (ethyl acetate). The solvent was evaporated under reduced pressure to give (3-bromo-4-ethoxyphenyl)methanol (2.98 g) as a white solid.

후처리

  1. customThe obtained reaction mixture
  2. filtrationwas filtered through celite
  3. customthe solvent was evaporated under reduced pressure
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-825de0de19a44d139f4af8e76ce0f888
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501804B2

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