Hydrochloric Acid → [5-(Methanesulfonyl)pyridin-2-yl]methanaminium chloride

HRID 1888829노트

반응식

HRID 1888829 반응식
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[N:12])=[N:9][CH:10]=1)(=[O:4])=[O:3].[ClH:13].[H][H]>CO.[Pd]>[ClH:13].[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][NH2:12])=[N:9][CH:10]=1)(=[O:4])=[O:3]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 591699295-(Methylsulfonyl)pyridine-2-carbonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 66725223[5-(Methanesulfonyl)pyridin-2-yl]methanaminium chloride수율 89%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

5-(Methylsulfonyl)pyridine-2-carbonitrile (2.15 g, 11.8 mmol) was dissolved in methanol (230 ml). 6M HCl (1 ml) and 10% palladium on carbon (2.34 mg) were added and the mixture was stirred under an atmospheric pressure of hydrogen overnight. The catalyst was removed by filtration through celite and the solvent was evaporated, water was added and the solution was freeze-dried to afford the title compound as a yellow powder (2.34 g, 89%).

후처리

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was evaporated
  3. additionwater was added
  4. customthe solution was freeze-dried

출처 및 근거

ORD 기록
ord-7357e64aaf5d464b8a870f42cac42a69
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501784B2

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