Hydrochloric Acid → 1,2-Thiazole-5-carbohydrazide
반응식
[S:1]1[C:5]([C:6]([NH:8][NH:9]C(OC(C)(C)C)=O)=[O:7])=[CH:4][CH:3]=[N:2]1.Cl>CO>[S:1]1[C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=[N:2]1참가 물질
4
실험 절차
A mixture of 1,1-dimethylethyl 2-(5-isothiazolylcarbonyl)hydrazinecarboxylate (I83) (480 mg, 1.973 mmol) in HCl (2 ml, 8.00 mmol) (4M in 1,4-dioxan) was stirred at room temperature under argon for 18 hours (overnight). After this time, the mixture was concentrated under reduced pressure to give a pale yellow coloured solid. The solid was dissolved in MeOH and passed through and SCX cartridge, eluting initially with MeOH and then with 2M NH3 in MeOH. The NH3/MeOH fractions were concentrated under reduced pressure to give a yellow coloured solid in 217 mg.
후처리
- concentrationAfter this time, the mixture was concentrated under reduced pressure
- customto give a pale yellow coloured solid
- washeluting initially with MeOH
- concentrationThe NH3/MeOH fractions were concentrated under reduced pressure
- customto give a yellow coloured solid in 217 mg
출처 및 근거
- ORD 기록
- ord-f2529446cf7d489fa598a871347a2e86
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08501946B2
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