Hydrazine hydrate (1:1) → HCID 178428523, 화합물
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8](=[NH:9])[NH:11][NH2:12])[N:3]=1참가 물질
4
실험 절차
4-methyl-2-pyrimidinecarbonitrile (I98)(0.190 g, 1.595 mmol) was dissolved in ethanol (3.19 ml) and hydrazine hydrate (0.100 ml, 3.19 mmol) was added. The reaction mixture was left at reflux for 2.5 hours. TLC showed that no starting material remained so the solvent was removed under reduced pressure to afford the crude desired product in 247 mg.
후처리
- waitThe reaction mixture was left
- temperatureat reflux for 2.5 hours
- customwas removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-1e337ac954234acbb6d2f95036a7e422
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08501946B2
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