Chloroacetone → Ethyl 4-methyl-1,3-thiazole-2-carboxylate

HRID 1889048

반응식

HRID 1889048 반응식
[NH2:1][C:2](=[S:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl[CH2:10][C:11](=O)[CH3:12]>C(O)C>[CH3:12][C:11]1[N:1]=[C:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[S:8][CH:10]=1

참가 물질

4

반응물 2

HCID 6571ChloroacetoneHCID 2733398Ethyl thiooxamate

생성물 1

HCID 567306Ethyl 4-methyl-1,3-thiazole-2-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl amino(thioxo)acetate (500 mg, 3.75 mmol) in ethanol (9.387 ml) was stirred at room temperature under an atmosphere of argon. 1-Chloro-2-propanone (0.299 ml, 3.75 mmol) was added and the solution was heated to reflux for 48 hours. The solution was allowed to cool to room temperature and then it was concentrated under reduced pressure to give a yellow coloured oily solid. The residue was chromatographed [SiO2, 0-100% EtOAc in Hexane] to give a yellow coloured oil identified as product in 208 mg.

후처리

  1. temperaturethe solution was heated
  2. temperatureto reflux for 48 hours
  3. concentrationit was concentrated under reduced pressure
  4. customto give a yellow coloured oily solid
  5. customThe residue was chromatographed [SiO2, 0-100% EtOAc in Hexane]
  6. customto give a yellow coloured oil

출처 및 근거

ORD 기록
ord-6c668f6c9e7f4e829153cb521dd36bea
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501946B2

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