Hydrazine → 4-Methyl-1,3-thiazole-2-carbohydrazide

HRID 1889049

반응식

HRID 1889049 반응식
[CH3:1][C:2]1[N:3]=[C:4]([C:7]([O:9]CC)=O)[S:5][CH:6]=1.[NH2:12][NH2:13]>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:7]([NH:12][NH2:13])=[O:9])[S:5][CH:6]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 567306Ethyl 4-methyl-1,3-thiazole-2-carboxylate

생성물 1

HCID 112289374-Methyl-1,3-thiazole-2-carbohydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl 4-methyl-1,3-thiazole-2-carboxylate (I120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg.

후처리

  1. temperaturethe solution was heated
  2. temperatureto reflux for 18 hours
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-98724bebacf9490c9529b3bed35afff4
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501946B2

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