Hydrochloric Acid → HCID 136348338, 화합물

HRID 1889447노트

반응식

HRID 1889447 반응식
[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].[ClH:41]>C(OCC)(=O)C.CC(C)=O>[ClH:41].[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 136052290HCID 136052290, 화합물

생성물 1

HCID 136348338HCID 136348338, 화합물수율 60%

시약·촉매·용매 2

HCID 180Acetone용매HCID 8857Ethyl Acetate용매

실험 절차

6-Ethyl-3-(2-morpholin-4-ylethyl)-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.26 g) was dissolved in ethyl acetate (8 mL) and acetone (2 mL), and 4N hydrochloric acid (ethyl acetate solution, 0.11 mL) was added. The precipitated solid was collected by filtration to give the title compound as colorless crystals (0.16. g, 60%).

후처리

  1. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-c0ae2862cef24835a89586b5f3572afa
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501750B2

반응 노트

불러오는 중…