5-Amino-2-methylpyridine → N(8)-(3-Methoxy-benzyl)-N(2)-(6-methyl-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

HRID 1890117

반응식

HRID 1890117 반응식
Cl[C:2]1[N:20]=[C:5]2[C:6]([NH:10][CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=3)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[CH3:21][C:22]1[N:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1>>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[CH2:11][NH:10][C:6]1[C:5]2[N:4]([N:3]=[C:2]([NH:28][C:25]3[CH:26]=[N:27][C:22]([CH3:21])=[CH:23][CH:24]=3)[N:20]=2)[CH:9]=[CH:8][CH:7]=1

참가 물질

3

반응물 2

HCID 2433135-Amino-2-methylpyridineHCID 67481427(2-Chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(3-methoxy-benzyl)-amine

생성물 1

HCID 59612599N(8)-(3-Methoxy-benzyl)-N(2)-(6-methyl-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

실험 절차

N(8)-(3-Methoxy-benzyl)-N(2)-(6-methyl-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine was prepared from (2-chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(3-methoxy-benzyl)-amine (99.9 mg, 0.346 mmol) and 6-methyl-pyridin-3-ylamine (41.91 mg, 0.3875 mmol) in a manner analogous to Example 2d. Product isolated as a red foam (8.55 mg, 7%). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.48 (s, 1H), 8.74 (s, 1H), 8.11 (d, J=8.2 Hz, 1H), 7.96 (d, J=6.7 Hz, 1H), 7.23 (t, J=15.8, 7.7 Hz, 1H), 7.15 (d, J=8.6 Hz, 1H), 6.96 (s, 2H), 6.82-6.70 (m, 2H), 6.57 (m, 1H), 6.31 (d, J=7.8 Hz, 1H), 4.48 (d, J=6.0 Hz, 2H), 3.71 (s, 3H), 2.40 (s, 3H). MS=361 (MH)+.

출처 및 근거

ORD 기록
ord-89bb504193ab416fa69449c2c29500f5
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501936B2

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