Sodium borohydride → HCID 67305210, 화합물

HRID 1890588노트

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HRID 1890588 반응식
[N:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[O:12].[BH4-].[Na+]>CO.C1COCC1>[N:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][OH:12]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 115863361,5-Naphthyridine-2-carbaldehyde

생성물 1

HCID 67305210HCID 67305210, 화합물수율 78%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a solution of 1,5-naphthyridine-2-carbaldehyde (8-3) (1.0 g, 6.32 mmol) in MeOH (15 mL) and THF (15 mL) was added NaBH4 (84 mg, 2.21 mmol). The reaction mixture was stirred at 0° C. for 0.5 h. The mixture was concentrated and purified by chromatography on silica gel to afford the title compound (790 mg).

후처리

  1. concentrationThe mixture was concentrated
  2. custompurified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-2ce50f4f79bb41e9a6fec590cc01ede6
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507487B2

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