Sodium hydride → 5-(3-Fluorophenyl)morpholin-3-one

HRID 1890670노트

반응식

HRID 1890670 반응식
Cl[CH2:2][C:3]([NH:5][CH:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)[CH2:7][OH:8])=[O:4].[H-].[Na+]>C1COCC1>[F:15][C:11]1[CH:10]=[C:9]([CH:6]2[NH:5][C:3](=[O:4])[CH2:2][O:8][CH2:7]2)[CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 24758Sodium hydrideHCID 583359312-chloro-N-(1-(3-fluorophenyl)-2-hydroxyethyl)acetamide

생성물 1

HCID 583357985-(3-Fluorophenyl)morpholin-3-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

In step 2-3, a solution of 2-chloro-N-(1-(3-fluorophenyl)-2-hydroxyethyl)acetamide (5.5 g, 24 mmol) in THF (150 mL) was slowly added to a suspension of NaH (1.05 g, 26 mmol) in THF (600 mL) at 0° C. The heterogeneous solution was warmed to room temperature and stirred overnight. The reaction mixtures was quenched, concentrated and ethyl acetate was added to the residue. This solution was washed with water and brine and the organic phase was dried over MgSO4, filtered and concentrated to yield 5-(3-fluorophenyl)morpholin-3-one (2-3).

후처리

  1. customThe reaction mixtures
  2. customwas quenched
  3. concentrationconcentrated
  4. additionethyl acetate was added to the residue
  5. washThis solution was washed with water and brine
  6. dry with materialthe organic phase was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7eb810cdbd964038a132a13ba3a076e7
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507488B2

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