Sodium borohydride → 2-(2,5-Difluorophenyl)pyrrolidine
반응식
[BH4-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[CH2:12][CH2:13][CH2:14][N:15]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH:11]1[CH2:12][CH2:13][CH2:14][NH:15]1참가 물질
4
실험 절차
In step 6A-3, sodium borohydride (2.1 g, 55.2 mmol) was added at room temperature to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (6-4) (5.0 g, 28 mmol) in anhydrous ethanol (150 mL). The reaction mixture was stirred over-night at room temperature. The ethanol was removed using a rotary evaporator and the resulting orange solid was reconstituted with ethyl acetate. The organic layer was washed with brine (3×150 mL), dried with sodium sulfate and the. ethyl acetate was removed to yield 2-(2,5-difluorophenyl)pyrrolidine (6-5) as a light yellow oil. m/z=184.2 [M+1].
후처리
- customThe ethanol was removed
- customa rotary evaporator
- washThe organic layer was washed with brine (3×150 mL)
- dry with materialdried with sodium sulfate
- customethyl acetate was removed
출처 및 근거
- ORD 기록
- ord-d911cd8a478e43d4ae312e818155d80c
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507488B2
반응 노트
불러오는 중…