Hydrochloric Acid → Ethyl 2-(2,4-difluorophenyl)acetimidate hydrochloride

반응식

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]#[N:11].[ClH:12].[CH2:13]([OH:15])[CH3:14]>>[ClH:12].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10](=[NH:11])[O:15][CH2:13][CH3:14]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 695652,4-Difluorophenylacetonitrile

생성물 1

HCID 67548940Ethyl 2-(2,4-difluorophenyl)acetimidate hydrochloride

실험 절차

Commercially available 2-(2,4-difluorophenyl)acetonitrile (Aldrich), HCl gas and ethanol were processed using the method described for Example 3A to obtain the titled compound except that the reaction time was 72 hours. MS (ESI+) m/z 200 (M+H)+.

출처 및 근거

ORD 기록: ord-5d0e595c88d541f780793188d692f7b7
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08507493B2

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