N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide → 1-(3-aminophenyl)-N,N-dimethylmethanesulfonamide

HRID 1890976노트

반응식

HRID 1890976 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Ni].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 28632733N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide

생성물 1

HCID 432562151-(3-aminophenyl)-N,N-dimethylmethanesulfonamide수율 96%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

(3-nitrophenyl)-N,N-dimethylmethanesulfonamide (2.32 g, 9.5 mmol) was hydrogenated over Raney nickel (0.5 g) in methanol at 50° C. and 70 psi for 4 h, then catalyst was filtered off, washed with warm methanol, combined filtrates were evaporated to give 1.95 g (96%) of (3-aminophenyl)-N,N-dimethylmethanesulfonamide.

후처리

  1. filtrationcatalyst was filtered off
  2. washwashed with warm methanol
  3. customwere evaporated

출처 및 근거

ORD 기록
ord-95216d08bd9a4a8a8340c3376e4a882b
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507498B2

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