methyl 3-acetyl-6-chloro-1H-indole-5-carboxylate → 3-acetyl-6-chloro-1H-indole-5-carboxylic acid

HRID 1891019노트

반응식

HRID 1891019 반응식
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([Cl:17])=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=2)[NH:6][CH:5]=1)(=[O:3])[CH3:2]>[OH-].[Na+].O1CCOCC1>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([Cl:17])=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=2)[NH:6][CH:5]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 67774875methyl 3-acetyl-6-chloro-1H-indole-5-carboxylate

생성물 1

HCID 677727683-acetyl-6-chloro-1H-indole-5-carboxylic acid수율 96%

시약·촉매·용매 2

HCID 14798Sodium Hydroxide용매HCID 312751,4-Dioxane용매

실험 절차

A solution of methyl 3-acetyl-6-chloro-1H-indole-5-carboxylate (0.21 g, 0.84 mmol) in 1.5 N sodium hydroxide (0.7 mL) and dioxane (0.5 mL) was heated at 60 C for 6 h and stirred overnight at room temperature. The reaction was quenched by the addition of acetic acid and diluted with water. The resulting solid was filtered, washed with water and dried in vacuo to give the title compound (0.17 g, 96%) as pale yellow powder, m/z=238 (M+H).

후처리

  1. customThe reaction was quenched by the addition of acetic acid
  2. additiondiluted with water
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-16c9e3526619438c92b2f5f37701ded0
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507499B2

반응 노트

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