Hydrochloric Acid → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

HRID 1891240노트

반응식

HRID 1891240 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26].[ClH:27]>ClCCl.CO.C(O)(C)C>[ClH:27].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 44233767{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

생성물 1

HCID 44233766{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

시약·촉매·용매 3

HCID 887Methanol용매HCID 3776Isopropanol용매HCID 6344Dichloromethane용매

실험 절차

A solution of 130 mg of {3-[2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridin-6-yl]phenyl}methanol in dichloromethane and methanol is passed through a frit and 3.7 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure. The residue obtained is triturated from diethyl ether and recovered by filtration and then oven-dried under reduced pressure. 128 mg of compound are obtained.

후처리

  1. additionare added to the filtrate
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. customThe residue obtained
  4. customis triturated from diethyl ether
  5. filtrationrecovered by filtration
  6. customoven-dried under reduced pressure

출처 및 근거

ORD 기록
ord-aab69326ba28499b866b5beeba3ca10a
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507520B2

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