Water → HCID 59637737, 화합물

HRID 1892019노트

반응식

HRID 1892019 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][C:11]#[C:12][Si:13]([CH3:16])([CH3:15])[CH3:14])=[O:8].[K].[C:18]1(=[O:28])[NH:22][C:21](=[O:23])[C:20]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:19]12.C(Cl)(Cl)Cl.O>CN(C=O)C>[C:18]1(=[O:28])[N:22]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][C:11]#[C:12][Si:13]([CH3:16])([CH3:15])[CH3:14])=[O:8])[C:21](=[O:23])[C:20]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:19]12

참가 물질

6

반응물 4

HCID 962WaterHCID 6212ChloroformHCID 24194345Phthalimide potassium saltHCID 59637735HCID 59637735, 화합물

생성물 1

HCID 59637737HCID 59637737, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-(trimethylsilyl)prop-2-ynyl 6-bromohexanoate (0.606 g, 2 mmol, 1 eq.) was added to a solution of phthalimide potassium salt (0.4412 g, 2.4 mmol, 1.2 eq.) in 50 mL of DMF and stirred overnight under argon. CHCl3 was added to the solution flask and was transferred to a separatory funnel containing water. The aqueous layer was separated and twice extracted with CHCl3. The combined organic layers were twice extracted with water then the solvent was removed on a rotary evaporator. Remaining solvent was removed under high vacuum overnight to yield a brown oil.

후처리

  1. customwas transferred to a separatory funnel
  2. customThe aqueous layer was separated
  3. extractiontwice extracted with CHCl3
  4. extractionThe combined organic layers were twice extracted with water
  5. customthe solvent was removed on a rotary evaporator
  6. customRemaining solvent was removed under high vacuum overnight
  7. customto yield a brown oil

출처 및 근거

ORD 기록
ord-1ca5145ce0074dfaa3e8a06dbd24ecd4
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507572B2

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